Enrofloxacin 10% Oral Solution for Pet Birds – 100 mg/mL Avian Antibiotic – 100 mL

Enrofloxacin 10% Oral Solution for Pet Birds (100 mL, 100 mg/mL): Uses, Dosing and Comparison

A bird that is fluffed up, eating poorly and passing watery droppings needs assessment before it needs a bottle. Several illnesses look alike, and a bird hides sickness until it is well advanced. When an avian veterinarian identifies a susceptible gram-negative bacterial infection and chooses enrofloxacin, this is the liquid formulation of that decision.

Enrofloxacin 10% Oral Solution contains 100 mg of enrofloxacin per millilitre in a 100 mL bottle. Enrofloxacin is a bactericidal fluoroquinolone, strongest against gram-negative bacteria such as E. coli, Salmonella and Pasteurella, also active against Mycoplasma, with limited activity against anaerobes.

This guide covers what the label states, what it deliberately does not, how the liquid differs from our powder, the safety points that matter with a fluoroquinolone, and when to stop reading and call a vet.

Important Notice: this product is for pet birds only. It is not for human use and not for poultry or other food-producing birds. Always consult a qualified avian veterinarian if you are unsure about diagnosis or treatment.

What Is Enrofloxacin 10% Oral Solution (100 mL)?

Enrofloxacin 10% Oral Solution is a ready-mixed liquid antibiotic for pet birds. The label states enrofloxacin 100 mg/ml, a net content of 100 mL, and that the bottle makes up to 20 gallons of medicated water.

Being a liquid changes how it is used. A powder is measured by the spoonful into a gallon of water for a whole loft; a solution can be measured in fractions of a millilitre for one bird, which is why it is the format a veterinarian reaches for when a single valuable bird needs an accurate dose. This 100 mL bottle suits a household aviary or a keeper treating a few birds.

Enrofloxacin is bactericidal: it inhibits bacterial DNA gyrase and topoisomerase IV, stopping DNA replication so susceptible bacteria die. That is a different mechanism from the bacteriostatic tylosin and doxycycline products in our range.

Product Details at a Glance

Attribute	Details
Active ingredient	Enrofloxacin
Concentration	100 mg per mL (10%)
Drug class	Fluoroquinolone antibiotic
Mechanism	Bactericidal; inhibits DNA gyrase and topoisomerase IV
Formulation	Ready-mixed oral solution
Net content	100 mL
Makes	Up to 20 gallons of medicated water
Spectrum	Strongest against gram-negative bacteria including E. coli, Salmonella and Pasteurella; also Mycoplasma; limited anaerobic activity
Labelled for	Pet birds only
Regulatory status (USA)	Supplied over the counter for pet birds. Not an FDA-approved animal drug, and extra-label fluoroquinolone use in food-producing animals is prohibited — see our legal and regulatory information
Storage	Cool, dry place out of direct sunlight; keep away from children and pets

What Enrofloxacin 10% Oral Solution (100 mL) Is Used For

This solution is intended for susceptible bacterial conditions, particularly those involving the gram-negative organisms below. The same visible sign can have several causes, and susceptibility cannot be judged from appearance.

Colibacillosis

Associated with Escherichia coli. A bird may be lethargic and fluffed up, have diarrhoea and sometimes respiratory signs. E. coli is among the gram-negative bacteria enrofloxacin covers, but those signs do not identify it without veterinary assessment.

Salmonellosis and paratyphoid

Associated with Salmonella species, and a familiar problem in pigeon lofts. Signs include watery or greenish droppings, weight loss, and swollen joints or wing joints. A change in droppings or a swollen joint alone cannot establish the diagnosis.

Pasteurella infections and cat injuries

Associated with Pasteurella multocida, classically after a cat bite or scratch. Enrofloxacin’s spectrum includes Pasteurella, but a cat-injured bird needs immediate veterinary care, not a home course.

Bacterial respiratory infections

Sneezing, nasal discharge or laboured breathing may prompt investigation. Mycoplasma is within the spectrum, as are gram-negative bacteria. Respiratory signs have many causes, so match the product to the assessed organism — our guide to the antibacterial classes explains how the classes differ.

How Does Enrofloxacin 10% Oral Solution (100 mL) Work?

Enrofloxacin kills susceptible bacteria by inhibiting DNA gyrase and topoisomerase IV, which stops bacterial DNA replication. Its strongest activity is against gram-negative bacteria, with additional Mycoplasma activity and limited anaerobic activity.

The practical consequence of the liquid format is precision: 100 mg per millilitre means a tenth of a millilitre carries 10 mg, so small differences in measurement matter. That is an argument for a syringe and a veterinary figure, not a kitchen spoon.

Enrofloxacin 10% Oral Solution (100 mL) Dosage and Administration

The label states the concentration and the volume. It does not state a dose, and neither do we. Here is exactly what the bottle tells you and what it leaves to your veterinarian.

What the label states	Value
Concentration	Enrofloxacin 100 mg per mL (10%)
Net content	100 mL
Makes up to	20 gallons of medicated water
Dose per bird	Not printed on the label — set by an avian veterinarian

Why we do not publish a dose for this bottle. A liquid is dosed by the
individual bird’s body weight, and a budgerigar, a pigeon and a macaw differ by orders of
magnitude. The bottle prints its concentration so a veterinarian can calculate from it; it does
not print a figure you can apply to your bird without that calculation. Ask your avian
veterinarian for the volume, the frequency and the number of days, and write it down.

Measuring accurately

Use a graduated oral syringe, not a dropper or a spoon. At 100 mg per millilitre the difference between 0.1 mL and 0.2 mL is 10 mg of antibiotic, which is significant for a small bird. Write down the volume and the times, and keep the bottle so the concentration can be checked if the bird is seen by a different clinician.

Safety, Side Effects, and Precautions

Fluoroquinolone stewardship

Fluoroquinolones are among the antibiotics human and veterinary medicine most need to keep working. Use enrofloxacin only for a confirmed or strongly suspected bacterial infection, at the dose your veterinarian sets, for the full course. A broad spectrum is a reason to be more careful, not less.

Never combine two enrofloxacin products

This solution and our Enrofloxacin 10% Powder contain the same active. Running both at once doubles the dose without anyone intending it. Use one product, finish the course, then reassess with your veterinarian.

Not for food-producing birds

US rules prohibit extra-label fluoroquinolone use in food-producing animals. Do not use this product in chickens, ducks, quail or turkeys kept for eggs or meat, and do not apply anything on this page to a food-producing flock. See our legal and regulatory information.

Mineral binding

Calcium, magnesium and iron reduce enrofloxacin absorption. Remove mineral blocks, cuttlebone, grit and mineral supplements during treatment, and confirm any dietary change with an avian veterinarian.

Cat bites and scratches are an emergency

Pasteurella from a cat’s mouth causes sudden, severe illness in birds. The puncture wounds are often tiny and hidden under feathers. Get immediate veterinary care rather than starting a course at home and waiting to see what happens.

Not effective against fungi, viruses or parasites

Enrofloxacin is an antibiotic with limited activity against anaerobic bacteria and none against fungi, viruses or parasites. A bird with diarrhoea or respiratory signs may have a cause outside its spectrum, which is why the diagnosis has to come first.

Storage and Shelf Life

Store the bottle in a cool, dry place out of direct sunlight, and keep it away from children and pets. Check the lot number and expiry date printed on the pack before use and do not use it past expiry. Once a bottle is opened, keep the cap clean and closed; if you dilute any of it into drinking water, make that fresh each day rather than keeping it.

Enrofloxacin 10% Oral Solution (100 mL) vs. Our Other Bird Medications

Enrofloxacin reaches birds in several formats in our range. They share an active ingredient and are not interchangeable by number: a 10% powder is 100 mg per gram, while a 10% solution is 100 mg per millilitre.

Product	Active ingredient	Strength	Best for	When to choose
Enrofloxacin 10% Oral Solution (100 mL) (this product)	Enrofloxacin	100 mg per mL	The gram-negative targets above	Accurate dosing of an individual bird, or dilution for a group
Enrofloxacin 10% Powder	Enrofloxacin	100 mg per gram	E. coli, Salmonella, Pasteurella, gram-negative infections	Flock or loft treatment through drinking water
Tylosin Powder	Tylosin tartrate	99% (990 mg per gram)	Mycoplasma, chronic respiratory disease, sinusitis	Respiratory signs where Mycoplasma is suspected
Doxycycline 20% Powder	Doxycycline	200 mg per gram	Psittacosis, Mycoplasma, bacterial respiratory infections	Suspected psittacosis
Doxy-Tyl Powder	Tylosin + doxycycline	40% + 20%	Mixed respiratory infections, Chlamydia + Mycoplasma	When both organisms may be involved
Vetafarm Trizole	Combination antiprotozoal	See pack	Canker, coccidiosis, giardia, hexamita	Protozoal problems, which antibiotics do not cover
All in One Powder	Blend of 5 actives, not named on the pack	Not stated	Canker, coccidiosis, respiratory and worm support	A loft programme on veterinary advice
Amoxicillin 10% Powder	Amoxicillin	10%	Susceptible bacterial infections	When a vet indicates a beta-lactam

Our recommendation: Get a diagnosis, then ask your veterinarian for a volume rather than looking one up. If you are treating one bird accurately, a solution is the right format; if you are running a loft through drinking water, the powder is usually more practical. Never run both.

Signs of Recovery and When to Seek Veterinary Help

What Recovery Looks Like

A recovering bird is less fluffed up and more alert. Appetite and drinking return to normal, usual activity and vocalizing resume, droppings return to their normal colour and consistency, and breathing becomes quiet without tail bobbing or open-mouth breathing. The label does not state how quickly that should happen, so judge progress on the signs.

When to Seek Professional Help

Seek immediate care after a cat bite or scratch, and prompt care for worsening breathing, open-mouth breathing, poor drinking, marked lethargy or any deterioration. Arrange reassessment if the bird does not improve on a confirmed plan. The Association of Avian Veterinarians (AAV) can help you find an avian vet.

Frequently Asked Questions About Enrofloxacin 10% Oral Solution (100 mL)

These answers cover what the label states, what it does not, and where a veterinarian has to make the call.

What is Enrofloxacin 10% Oral Solution (100 mL)?

A ready-mixed liquid fluoroquinolone antibiotic for pet birds containing 100 mg of enrofloxacin per millilitre, in a 100 mL bottle that makes up to 20 gallons of medicated water. It is strongest against gram-negative bacteria.

How much should I give my bird?

The label states the concentration, not a dose. Liquids are dosed by body weight, and a budgerigar and a macaw differ enormously, so the volume has to come from an avian veterinarian who has weighed and assessed your bird.

Is this the same as your Enrofloxacin 10% Powder?

The active ingredient is the same but the formulations are not interchangeable. The powder is 100 mg per GRAM and is mixed into drinking water; this is a liquid at 100 mg per MILLILITRE. Never carry a dose from one to the other.

What should I do if a cat bites or scratches my bird?

Get immediate avian veterinary care. Pasteurella from a cat’s mouth can cause sudden, severe illness, and the puncture wounds are often tiny and hidden under feathers. Do not wait to see whether symptoms develop.

Should I remove mineral blocks during treatment?

Yes. Calcium, magnesium and iron bind enrofloxacin and reduce absorption, so remove mineral blocks, cuttlebone, grit and mineral supplements during the course, and confirm the bird’s nutritional plan with your veterinarian.

Can this be used for chickens or other poultry?

No. US rules prohibit extra-label fluoroquinolone use in food-producing animals, and the label is for pet birds. That includes chickens, ducks, quail and turkeys kept for eggs or meat.

What if my bird will not take it?

Contact an avian veterinarian promptly. A bird that refuses a medication, or that is too unwell to swallow, needs a different route rather than a larger dose.

How should I measure it?

With a graduated oral syringe. At 100 mg per millilitre, a tenth of a millilitre is 10 mg of antibiotic, so a dropper or a spoon is not accurate enough for a small bird.

How long does an opened bottle last?

Check the expiry date printed on the pack and keep the bottle closed, cool and out of sunlight. Any portion you dilute into drinking water should be made fresh daily rather than kept.

Conclusion

Enrofloxacin 10% Oral Solution supplies 100 mg of enrofloxacin per millilitre in a 100 mL bottle that makes up to 20 gallons of medicated water. Its bactericidal fluoroquinolone action covers susceptible E. coli, Salmonella, Pasteurella and Mycoplasma, and it does not treat fungi, viruses or parasites.

Use it only on a veterinary diagnosis and a veterinary dose, measured with a syringe. Do not run it alongside our enrofloxacin powder, remove mineral sources during the course, and treat a cat bite or scratch as an emergency.

Ready to treat? Enrofloxacin 10% Oral Solution, 100 mg/mL, 100 mL is in stock and dispatched the same business day on orders placed before 2:00 PM ET, shipped tracked within the United States.

Related Products

These products have related or complementary roles.

• Enrofloxacin 10% Powder — the same active for drinking-water treatment of a loft.
• Doxycycline 20% Powder — for suspected psittacosis and other respiratory concerns.
• Vetafarm Trizole — for canker, coccidiosis and related protozoa, which antibiotics do not cover.
• Browse all bird antibiotics or read our guide to the antibacterial classes.

External Resources

Use these veterinary resources alongside advice for your individual bird.

• Association of Avian Veterinarians (AAV)
• American Veterinary Medical Association (AVMA)
• Merck Veterinary Manual
• FDA Center for Veterinary Medicine

Disclaimer: This page is general husbandry information, not veterinary advice and not a dosing instruction. This product is intended exclusively for the animals named on its label. It is not for human consumption and not for poultry or other food-producing birds. Consult a qualified avian veterinarian for diagnosis and treatment.